Department of Oral Medicine
Director, Oral Medicine Research Program
Dr. Akintoye is a clinician-scientist with interest in basic and translational research related to alleviating orofacial complications of cancer therapy. His research is focused on orofacial bone mesenchymal stem cells, site-specific characteristics and therapeutic applications as donor graft to bridge osseous defects in the maxillofacial region.
Dr. Akintoye’s laboratory reported that human orofacial mesenchymal stem cells within the jaw bone are unique and different from those in non-oral skeletal sites in terms of their growth, lifespan and bone regenerative properties. He is studying the modulatory roles of orofacial bone mesenchymal stem cells in the pathogenesis of jaw osteonecrosis and how their unique properties can be harnessed for oral bone healing.
Dr. Akintoye is also interested in dental manifestations of metabolic bone diseases. He has focused on fibrous dysplasia and described the dental features of maxillo-mandibular fibrous dysplasia associated with McCune-Albright syndrome.
Dr. Akintoye’s research has received support from the National Cancer Institute, National Institute of Dental and Craniofacial Research, American Cancer Society, University of Pennsylvania Research Foundation, Penn Center for Musculoskeletal Disorders, Penn Institute for Regenerative Medicine and Private Foundations. Dr. Akintoye teaches in the Oral Diagnosis and Admissions Clinic and in the graduate programs of the Division of Advanced Dental Education.