Claire Mitchell, PhD. Associate Professor Contact Information Robert Schattner Center University of Pennsylvania School of Dental Medicine 240 South 40th Street Philadelphia, PA 19104-6030 Phone: 215-573-2176 Fax: 215-573-3834 Email: chm@mail.med.upenn.edu Web: Biomedical Graduate Studies Penn Medicine, Department of Physiology

Education

• Ph.D. Physiology University College London, UK, 1994
• B.Sc. Biology McGill University, Canada, 1986

Honors/Credentials

• University Research Foundation Award, 2003
• NRSA Fellowship in Respiratory Physiology, 1996
• NRSA Fellowship in Neuroscience, 1995
• Royal National Institute for the Blind Fellowship, 1992
• Fight for Sight Ph.D. Studentship Award, 1988

Research Interests
Dr. Mitchell's research uses physiological approaches to understand the mechanistic steps of disease. For example, the lab is currently investigating how elevated pressure leads to neuronal death, focusing on ATP release, pannexin hemichannels, P2X7 receptors, NMDA receptors and the neuroprotective actions of A 3 adenosine receptors. The role of these components in cytokine release is also being probed. In addition, the lab is exploring the physiology of lysosomes, with investigations into the regulation of lysosomal pH in health and disease. Pharmacological and molecular manipulation of lysosomal Cl- channels such as CFTR and CLC-7 is being used to reacidify lysosomes and improve degradative activity in aging and diseased cells.

 

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