Information on the impact of coronavirus (COVID-19) on patient care and School/University operations. Plus, resources for the Penn Dental Medicine community and alumni.
Hyun (Michel) Koo, MS, PhD »
Department of Orthodontics, Division of Community Oral Health, Division of Pediatric Dentistry
The laboratory of Dr. Koo focuses on understanding the relationship between biofilms and oral infectious diseases and seeking novel therapeutic strategies to control pathogenic biofilms, including those associated with dental caries. Dr. Koo is developing new therapeutic approaches to target biofilm at its core using synthetic as well as naturally occurring agents, including nanotechnology-based drug carriers and compounds in cranberries.
Henry Daniell, PhD »
Vice-Chair and W.D. Miller Professor
Department of Basic & Translational Sciences
Inspired by issues of healthcare inequity and global human rights, Henry Daniell has developed and advanced a novel approach to orally delivering affordable biopharmaceuticals, eliminating expensive injections and refrigeration. He has developed drugs to treat dental caries, diabetes, hemophilia, pulmonary hypertension, diabetic retinopathy, and Alzheimer’s disease, as well as oral vaccines for cholera, tuberculosis, malaria, polio, and plague.
Anh Le, DDS, PhD »
Chair and Norman Vine Endowed Professor of Oral Rehabilitation
Department of Oral and Maxillofacial Surgery / Pharmacology
Dr. Le’s research focuses on investigating mesenchymal stem cells from adult oral tissues. Together with collaborators, she isolated and characterized adult stem cells from gingival tissue—a discovery she patented while at USC. Studying those stem cells further, Dr. Le proposed a new mechanism by which they might aid in wound healing; they proposed that the stem cells may modify the environment of the wound.
Sinem Esra Sahingur, DDS, MS, PhD »
Associate Dean of Graduate Studies & Student Research, Associate Professor
Department of Periodontics
Dr. Sahingur’s research program has been continuously funded by federal and non-federal grants and focuses on defining the role of immune and inflammatory pathways in periodontal disease pathogenesis, genetic and epigenetic susceptibility to periodontitis and the link between oral and systemic diseases. Sahingur and her team initiated the studies that revealed the involvement of nucleic acid sensing and ubiquitination in periodontal disease pathogenesis and more recently the link between oral cavity, gut, and liver axis.
Shuying (Sheri) Yang, MD, MS, PhD »
Department of Basic & Translational Sciences
Dr. Yang’s research interests focus on exploring the mechanism of tooth and bone development, bone metabolism and mechanostransduction, as well as gene/stem cell therapy of bone diseases. Research in Dr. Yang’s lab has provided significant insights into the regulation of bone remodeling and bone resorption by the calcium oscillation, GPCR/G protein/RGS signaling pathways, primary cilia, IFT80 and IFT20 in regulation of bone cell behavior/bone and cartilage formation, which bridged the gap about the function and mechanism of RGS and ciliary IFT proteins in skeleton.
Flavia Teles, DDS, MS, DMSc »
Departent of Basic & Translational Sciences
Dr. Teles’ interests include the study of the oral microbiome in health, disease initiation, progression and in response to periodontal treatment and implant placement as well as the investigation of the microbial ecology of the oral cavity. For the past ten years, her research activities in the have been supported by grants from NIH/NIDCR, industry and foundations.
Geelsu Hwang, PhD
Preventive & Restorative Sciences
Dr. Hwang’s research is centered on applying engineering principles and tools to understand the pathogenesis of various biofilm-associated oral diseases, and to develop therapeutic approaches. His research also includes the dynamic interplay between host and microbes in the context of infectious oral disease. He has published extensively in the area of biofilm research using engineering, biochemical/biophysical, confocal imaging methodologies and mathematical modeling.
Chider Chen, PhD »
Department of Oral & Maxillofacial Surgery / Pharmacology
Dr. Chen’s research focuses on stem cell biology and stem cell-based therapy for craniofacial and immune-related diseases, in which several novel physiological mechanisms have been identified. These findings have been translated into several pilot clinical studies to treat human patients with autoimmune diseases such as Systemic Lupus Erythematosus and Systemic Sclerosis; however, the reasons behind this stem cell-based therapy are not fully understood.
Kathleen Stebe, MSE, PhD »
Goodwin Professor of Engineering and Applied Science
Kate’s primary research interests are in non-equilibrium interfaces, with applications ranging from microfluidics to nanotechnology. One aspect of her research program focuses on interfaces between fluids and how surfactants can be used to influence interfacial flows. Other aspects address tailoring of solid-liquid interfaces with applications ranging from patterned electrodeposition to capillary-driven assembly and ordering of nanomaterials.
Jason Moore, PhD »
Edward Rose Professor of Informatics & Director of the Penn Institute for Biomedical Informatics
Dr. Moore leads an active NIH-funded research program focused on the development of artificial intelligence and machine learning algorithms for the analysis of complex biomedical data with a focus on genetics and genomics. He is an elected fellow of the American Association for the Advancement of Science (AAAS), an elected fellow of the American College of Medical Informatics (ACMI), and was selected as a Kavli fellow of the National Academy of Sciences.
Daeyoon Lee, PhD »
Professor of Chemical and Biomolecular Engineering
School of Engineering and Applied Science
The vision of Daeyeon and the Soft Materials Research and Technology (SMART) Lab is to develop deep understanding of the interactions between soft materials. His group seeks to extend the obtained knowledge to enable the assembly of nano-/micro-scale materials into macroscopic structures that have designed properties and functionality. The major research efforts in the lab include understanding the behavior of Janus particles at fluid interfaces, understanding and improving the assembly and mechanical properties of nanoparticle films, the generation of hierarchical structures using emulsions and bubbles as templates, and development of catalytic systems for biomass conversion.
Andrew Tsourkas, PhD »
Professor, Department of Bioengineering
Co-Director, Center for Targeted Therapeutics & Translational Nanomedicine (CT3N)
Co-Director, Chemical and Nanoparticle Synthesis Core
The Tsourkas lab combines chemistry, nanotechnology, and protein engineering to create novel targeted imaging and therapeutic agents designed to improve the detection and treatment of cancer. Specific research interests include (i) developing new nanoformulations that are capable of carrying extremely high payloads of drugs, sensitizing agents, and/or contrast agents; (ii) investigating new disease targeting strategies that maximize specificity and sensitivity; and (iii) developing new bioconjugation techniques that enable the highly efficient, site-specific labeling of targeting agents for imaging and therapeutic applications.
Junhyong Kim, PhD »
Patricia M. Williams Term Professor and Chair, Biology; Co-Director, Penn Program in Single Cell Biology; Adjunct Professor, Computer and Information Science
Penn Arts & Sciences
Dr. Kim’s lab works at the interface of Genomics, Computational/Mathematical Biology, and Evolution. We employ both quantitative modeling and experimental methods to understand the fundamental mechanisms that govern dynamical processes in an organism and the evolution of such processes. We employ a wide variety of systems and collaborate broadly with colleagues from different disciplines.
David Cormode, DPhil »
Associate Professor of Radiology
Perelman School of Medicine
Dr. Cormode’s research focuses on the development of novel and multifunctional nanoparticle contrast agents for medical imaging applications. A current major area is the development of gold and bismuth nanoparticles as contrast agents for computed tomography (CT). The nanoparticles can be further modified to have a variety of additional functional properties, such as fluorescence, MRI contrast or therapeutic effects. Related areas of interest are novel computed tomography-based imaging methods, such as dual energy CT, spectral CT and iterative image reconstruction. These technologies are being applied for structural imaging and molecular imaging of the levels of specific cell types and proteins in vivo. These approaches provide enhanced characterization of cardiovascular diseases and cancers, which should allow improved selection of therapies and monitoring of response to treatments.
Ravi Radhakrishnan, PhD »
Chair and Professor
Bioengineering, Chemical and Biomolecular Engineering
Ravi’s research interests lie at the interface of chemical physics and molecular biology. His lab’s goal is to provide atomic and molecular level characterization of complex biomolecular systems and formulate quantitatively accurate microscopic models for predicting the interactions of various therapeutic agents with innate biochemical signaling mechanisms. To do so, they employ several computational algorithms ranging from techniques to treat electronic structure, molecular dynamics, Monte Carlo simulations, stochastic kinetic equations, and complex systems analyses in conjunction with the theoretical formalisms of statistical and quantum mechanics, and high performance computing in massively parallel architectures.
Dongeun (Dan) Huh, MS, PhD »
Dr. Huh’s laboratory aims to develop innovative bioengineering tools and technologies using biologically inspired design principles and micro/nanoengineering approaches to improve human health and promote environmental sustainability. Huh’s research focuses primarily on developing i) microengineered biomimetic models of human organs (organs-on-chips), ii) self-assembled tissue/organ scaffolds, iii) cell-based self-regulating “smart” biomedical devices, and iv) efficient biomimetic transport systems. Huh explores the use of these bioinspired engineering systems for a variety of biomedical, pharmaceutical, and environmental applications.
David Issadore, MA, PhD »
Electrical and Systems Engineering (ESE)
Dr. Issadore’s research focus is on microelectronics, microfluidics, nanomaterials and molecular targeting, and their application to medicine. These multidisciplinary skills enable him to explore new technologies that can bring medical diagnostics from expensive, centralized facilities, directly to clinical and resource-limited settings. He has developed hybrid chip designs, a portable NMR system and the micro Hall detector.
Cesar de la Fuente Nunez, PhD »
Presidental Assistant Professor
The de la Fuente Lab is based in the Department of Bioengineering and the Departments of Microbiology, and Psychiatry in the Perelman School of Medicine at the University of Pennsylvania. We draw on protein design, synthetic biology, bioengineering, microbiology, and computational biology to establish foundational platforms for the engineering of biological systems. We use the principles and tools of these diverse disciplines to tackle a wide range of global health challenges. Our overarching goal is to find solutions to the world’s hardest biomedical problems, including antibiotic resistance, infectious diseases, cancer, and microbiome engineering.
James Pikul, MS, PhD »
Mechanical Engineering and Applied Mechanics (MEAM)
Dr. Pikul seeks to make transformative advances in energy storage, energy conversion, and multifunctional materials by understanding and exploiting characteristics of materials at the micro and nano scales. He is developing hierarchical battery electrodes that reduce ion and electron transport resistances so that batteries can charge/discharge faster and dissipate heat more quickly. James also researches large area nano-manufacturing technologies to enable material systems with enhanced structural and chemical functionality. These materials systems are inspired by the complex functionalities in natural materials (like self-healing bone fractures), but utilize modern engineering and design principles to achieve mechanical and chemical properties not available in natural or man-made materials.
Michael J. Mitchell, MS, PhD
Skirkanich Assistant Professor of Innovation
The Mitchell Lab is based in the Department of Bioengineering at the University of Pennsylvania. Our research lies at the interface of biomaterials science, drug delivery, and cellular and molecular bioengineering to fundamentally understand and therapeutically target biological barriers. We apply our research findings and the technologies developed to a range of human health applications, including cancer metastasis, immunotherapy, genome editing, cardiovascular disease, and regenerative medicine. Current research projects include: synthesis of novel biomaterials and nanoparticles for the delivery of nucleic acids (siRNA, miRNA, mRNA, CRISPR-Cas9) for cancer therapy; engineering of immune cells for immunotherapy and vaccines; investigating the influence of biomaterial chemical structure on in vivo transport to target cells and tissues using high-throughput screening platforms; and novel drug delivery technologies for tissue engineering and regenerative medicine. Mike has received an NIH National Research Service Award, the NIH Director’s New Innovator Award, and a Career Award at the Scientific Interface from the Burroughs Wellcome Fund, recognizing interdisciplinary researchers who are “bridging science fiction with reality.”