A quick update on Penn Dental Medicine research with a snapshot of recent publications and research grant awards:
Following is a selection of recent publications from Penn Dental Medicine standing faculty — those papers recently added to PubMed; those articles in which faculty were first/last authors include the abstract of the publication.From the Dept. of Anatomy and Cell Biology:
Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation.
Gómez NM, Lu W, Lim JC, Kiselyov K, Campagno KE, Grishchuk Y, Slaugenhaupt SA, Pfeffer BA, Fliesler SJ, Mitchell CH.
FASEB J. 2017 Oct 13. pii: fj.201700220RR. doi: 10.1096/fj.201700220RR. [Epub ahead of print]
PMID: 29030399 [PubMed – as supplied by publisher]
Evidence for Kaposi’s Sarcoma originating from Mesenchymal Stem Cell through KSHV-induced Mesenchymal-to-Endothelial Transition.
Li Y, Zhong C, Liu D, Yu W, Chen W, Wang Y, Shi S, Yuan Y.
Cancer Res. 2017 Oct 24. pii: canres.1961.2017. doi: 10.1158/0008-5472.CAN-17-1961. [Epub ahead of print]
PMID: 29066510 [PubMed – as supplied by publisher]
Antimicrobial Peptide Combined with BMP2-Modified Mesenchymal Stem Cells Promotes Calvarial Repair in an Osteolytic Model.
Liu Z, Yuan X, Liu M, Fernandes G, Zhang Y, Yang S, Ionita CN, Yang S.
Mol Ther. 2017 Sep 14. pii: S1525-0016(17)30425-2. doi: 10.1016/j.ymthe.2017.09.011. [Epub ahead of print]
PMID: 28988712 [PubMed – as supplied by publisher]
From the Dept. of Endodontics:
Methodological Quality Assessment of Meta-analyses in Endodontics.
Kattan S, Lee SM, Kohli MR, Setzer FC, Karabucak B.
J Endod. 2017 Oct 9. pii: S0099-2399(17)30908-1. doi: 10.1016/j.joen.2017.07.019. [Epub ahead of print] Review.
PMID: 29032820 [PubMed – as supplied by publisher]
From the Dept. of Microbiology:
Meeting report: The 12th European oral microbiology workshop (EOMW) in Stockholm, Sweden.
Belibasakis GN, Curtis MA, Hajishengallis G, Zaura E.
Virulence. 2017 Sep 7:1-6. doi: 10.1080/21505594.2017.1376147. [Epub ahead of print] No abstract available.
PMID: 28881167 [PubMed – as supplied by publisher]
Safety and Efficacy of the Complement Inhibitor AMY-101 in a Natural Model of Periodontitis in Non-human Primates.
Kajikawa T, Briones RA, Resuello RRG, Tuplano JV, Reis ES, Hajishengallis E, Garcia CAG, Yancopoulou D, Lambris JD, Hajishengallis G.
Mol Ther Methods Clin Dev. 2017 Aug 18;6:207-215. doi: 10.1016/j.omtm.2017.08.001. eCollection 2017 Sep 15.
PMID: 28879212 [PubMed] Free PMC Article
From the Dept. of Oral Medicine:
Evidence-based clinical practice guideline for the evaluation of potentially malignant disorders in the oral cavity: A report of the American Dental Association.
Lingen MW, Abt E, Agrawal N, Chaturvedi AK, Cohen E, D’Souza G, Gurenlian J, Kalmar JR, Kerr AR, Lambert PM, Patton LL, Sollecito TP, Truelove E, Tampi MP, Urquhart O, Banfield L, Carrasco-Labra A.
J Am Dent Assoc. 2017 Oct;148(10):712-727.e10. doi: 10.1016/j.adaj.2017.07.032.
PMID: 28958308 [PubMed – in process]
Adjuncts for the evaluation of potentially malignant disorders in the oral cavity: Diagnostic test accuracy systematic review and meta-analysis-a report of the American Dental Association.
Lingen MW, Tampi MP, Urquhart O, Abt E, Agrawal N, Chaturvedi AK, Cohen E, D’Souza G, Gurenlian J, Kalmar JR, Kerr AR, Lambert PM, Patton LL, Sollecito TP, Truelove E, Banfield L, Carrasco-Labra A.
J Am Dent Assoc. 2017 Nov;148(11):797-813.e52. doi: 10.1016/j.adaj.2017.08.045. Review.
PMID: 29080605 [PubMed – in process]
From the Depts. of Oral Medicine & Oral Surgery/Pharmacology:
A treatment algorithm for the management of intraoral burns: A narrative review.
Kang S, Kufta K, Sollecito TP, Panchal N.
Burns. 2017 Oct 9. pii: S0305-4179(17)30491-6. doi: 10.1016/j.burns.2017.09.006. [Epub ahead of print] Review.
PMID: 29032979 [PubMed – as supplied by publisher]
From the Depts. of Oral Surgery:
Cardiovascular considerations for the dental practitioner. 1. Review of cardiac anatomy and preoperative evaluation.
Kufta K, Saraghi M, Giannakopoulos H.
Gen Dent. 2017 Nov-Dec;65(6):50-55.
PMID: 29099366 [PubMed – in process]
Lack of Methemoglobin Elevations After Topical Applications of Benzocaine Alone or Benzocaine Plus Tetracaine to the Oral Mucosa.
Wang S, Giannakopoulos H, Lowstetter J, Kaye L, Lee C, Secreto S, Ho V, Hutcheson MC, Farrar JT, Wang P, Doyle G, Cooper SA, Hersh EV.
Clin Ther. 2017 Oct;39(10):2103-2108. doi: 10.1016/j.clinthera.2017.08.017. Epub 2017 Sep 22.
PMID: 28943117 [PubMed – in process]
Odontogenic sinusitis: developments in diagnosis, microbiology, and treatment.
Workman AD, Granquist EJ, Adappa ND.
Curr Opin Otolaryngol Head Neck Surg. 2017 Oct 27. doi: 10.1097/MOO.0000000000000430. [Epub ahead of print]
PMID: 29084007 [PubMed – as supplied by publisher]
From the Dept. of Orthodontics & Divs. of Pediatric Dentistry & Community Oral Health:
Oral Biofilms: Pathogens, Matrix, and Polymicrobial Interactions in Microenvironments.
Bowen WH, Burne RA, Wu H, Koo H.
Trends Microbiol. 2017 Oct 30. pii: S0966-842X(17)30213-5. doi: 10.1016/j.tim.2017.09.008. [Epub ahead of print] Review.
PMID: 29097091 [PubMed – as supplied by publisher]
Emerging Biomedical Applications of Enzyme-Like Catalytic Nanomaterials.
Cormode DP, Gao L, Koo H.
Trends Biotechnol. 2017 Oct 26. pii: S0167-7799(17)30250-0. doi: 10.1016/j.tibtech.2017.09.006. [Epub ahead of print] Review.
PMID: 29102240 [PubMed – as supplied by publisher]
Nonleachable Imidazolium-Incorporated Composite for Disruption of Bacterial Clustering, Exopolysaccharide-Matrix Assembly, and Enhanced Biofilm Removal.
Hwang G, Koltisko B, Jin X, Koo H.
ACS Appl Mater Interfaces. 2017 Nov 8;9(44):38270-38280. doi: 10.1021/acsami.7b11558. Epub 2017 Oct 25.
PMID: 29020439 [PubMed – in process]
Targeting microbial biofilms: current and prospective therapeutic strategies.
Koo H, Allan RN, Howlin RP, Stoodley P, Hall-Stoodley L.
Nat Rev Microbiol. 2017 Dec;15(12):740-755. doi: 10.1038/nrmicro.2017.99. Epub 2017 Sep 25. Review.
PMID: 28944770 [PubMed – indexed for MEDLINE]
From the Dept. of Pathology:
Differential Effects of Antiretroviral Drugs on Neurons In Vitro: Roles for Oxidative Stress and Integrated Stress Response.
Stern AL, Lee RN, Panvelker N, Li J, Harowitz J, Jordan-Sciutto KL, Akay-Espinoza C.
J Neuroimmune Pharmacol. 2017 Aug 31. doi: 10.1007/s11481-017-9761-6. [Epub ahead of print]
PMID: 28861811 [PubMed – as supplied by publisher]
From the Dept. of Periodontics:
Effects of nerve cells and adhesion molecules on nerve conduit for peripheral nerve regeneration.
Chung JR, Choi JW, Fiorellini JP, Hwang KG, Park CJ.
J Dent Anesth Pain Med. 2017 Sep;17(3):191-198. doi: 10.17245/jdapm.2017.17.3.191. Epub 2017 Sep 25.
PMID: 29090249 [PubMed] Free PMC Article
FOXO1 Regulates Bacteria-Induced Neutrophil Activity.
Dong G, Song L, Tian C, Wang Y, Miao F, Zheng J, Lu C, Alsadun S, Graves DT.
Front Immunol. 2017 Sep 4;8:1088. doi: 10.3389/fimmu.2017.01088. eCollection 2017.
PMID: 28928749 [PubMed] Free PMC Article
Authors’ reply: Predictive diagnostic tests in periodontal diseases.
Kinane DF, Stathopoulou PG, Papapanou PN.
Nat Rev Dis Primers. 2017 Sep 14;3:17070. doi: 10.1038/nrdp.2017.70. No abstract available.
PMID: 28905942 [PubMed – in process]
Patterns of periodontal disease progression based on linear mixed models of clinical attachment loss.
Teles R, Moss K, Preisser JS, Genco R, Giannobile WV, Corby P, Garcia N, Jared H, Torresyap G, Salazar E, Moya J, Howard C, Schifferle R, Falkner KL, Gillespie J, Dixon D, Cugini M.
J Clin Periodontol. 2017 Oct 6. doi: 10.1111/jcpe.12827. [Epub ahead of print]
PMID: 28985450 [PubMed – as supplied by publisher]
FOXO1 deletion in keratinocytes improves diabetic wound healing through MMP9 regulation.
Zhang C, Lim J, Jeon HH, Xu F, Tian C, Miao F, Hameedaldeen A, Graves DT.
Sci Rep. 2017 Sep 5;7(1):10565. doi: 10.1038/s41598-017-10999-3.
PMID: 28874756 [PubMed – in process]
From the Dept. of Preventive & Restorative Sciences:
The 2nd Biennial IAAD Meeting.
J Adhes Dent. 2017;19(4):365-366. doi: 10.3290/j.jad.a39016. No abstract available.
PMID: 28930306 [PubMed – in process]
Performance of CAD/CAM monolithic ceramic Implant-supported restorations bonded to titanium inserts: A systematic review.
Conejo J, Kobayashi T, Anadioti E, Blatz MB.
Eur J Oral Implantol. 2017;10 Suppl 1:139-146.
PMID: 28944374 [PubMed – in process]
Goodacre CJ, Blatz MB.
Eur J Oral Implantol. 2017;10 Suppl 1:3. No abstract available.
PMID: 28944364 [PubMed – in process]
Flexural strength of fiber reinforced posts after mechanical aging by simulated chewing forces.
Irmak Ö, Yaman BC, Lee DY, Orhan EO, Mante FK, Ozer F.
J Mech Behav Biomed Mater. 2018 Jan;77:135-139. doi: 10.1016/j.jmbbm.2017.09.001. Epub 2017 Sep 5.
PMID: 28898724 [PubMed – in process]
Effect of rubbing force magnitude on bond strength of universal adhesives applied in self-etch mode.
Irmak Ö, Yaman BC, Orhan EO, Ozer F, Blatz MB.
Dent Mater J. 2017 Oct 27. doi: 10.4012/dmj.2017-018. [Epub ahead of print]
PMID: 29081447 [PubMed – as supplied by publisher]
Effect of thickness and surface modifications on flexural strength of monolithic zirconia.
Ozer F, Naden A, Turp V, Mante F, Sen D, Blatz MB.
J Prosthet Dent. 2017 Oct 14. pii: S0022-3913(17)30565-6. doi: 10.1016/j.prosdent.2017.08.007. [Epub ahead of print]
PMID: 29042115 [PubMed – as supplied by publisher]
(Please Note: Due to the variable nature of when publishers index articles to PubMed, there may be some articles that have come out recently that do not yet appear in the PubMed database, and given the variable nature of when publishers index articles to PubMed, some older articles may only have been added to PubMed recently.)
Department of Biochemistry
Oral Tolerance for Hemophilia
The current standard of care for the X-linked bleeding disorder hemophilia is intravenous infusion of recombinant factor VIII (FVIII, for hemophilia A). FVIII is expensive, requires frequent repeated IV injections, and are often targeted by antibody responses, thereby complicating/neutralizing therapy, creating immunotoxicities, and further increasing costs. The goals of this project are to: 1) Develop the next generation of edible transplastomic plants expressing FVIII antigen, ovalbumin, or IL-10 fused to different transmucosal carriers, using cutting-edge chloroplast genetic engineering tools. 2) Continue to define the mechanism of oral tolerance induction/immune regulation, in part through use of a model antigen. 3) Suppress inhibitor formation against FVIII in hemophilia A dogs and develop combination oral immune modulatory therapies.
Funding Source: University of Florida, NIH
Principal Investigator: Dr. Henry Daniell, Professor and Interim Chair
Department of Microbiology
Advanced Design of Tumor Targeted, Neutralization Resistant oHSV Vectors
This study will focus on targeting metastatic cancer tumors with a new weapon: herpes. Viruses have been used to treat tumors before by causing the body to attack foreign invaders, but these viruses can fall short when the body creates antibodies to destroy the virus. Dr. Cohen and a colleague from the University of Pittsburgh will work to create a breakthrough herpes virus that specifically targets tumors and is highly-resistant to antibodies. This would help treat patients’ tumors more effectively and safely than existing treatments.
Funding Source: Spirit Award, NIH
Principal Investigator: Dr. Gary Cohen, Professor
Development of a Novel Antiviral to Treat/Prevent Acyclovir Resistance in Human Ocular Herpes Keratitis
The goal of this Phase I STTR is to initiate the development of an antiviral drug that can be used alone or in combination with ACV in order to diminish the chances of generating viral resistant mutants in recurrent treatment of human ocular herpes keratitis. Dr. Ricciardi’s lab has discovered a potent lead that blocks HSV-1 infection and his studies on FHV-1 also provide a foundation to potentially use the feline natural model for a future SBIR Phase II study
Funding Source: Fox Chase Chemical Diversity Center, NIH
Principal Investigator: Dr. Robert Ricciardi, Professor and Chair
A New Model of Regenerative Wound Healing via Inflammation-Modulating Biomaterial
The potential to regain bone and attachment via drug modulation of a regenerative response would represent an ideal advance in periodontal therapy. This study will test the hypothesis that modulating the HIF-1α environment via an injectable HIF-1α agonist drug/hydrogel construct can lead to significant bone regeneration. This will be tested in the context of bacterially-induced, immune-mediated PD in mice, a validated model of human PD.
Funding Source: Lankenau Institute for Medical Research, NIH
Principal Investigator: Dr. George Hajishengallis, Professor
Department of Oral Surgery/Pharmacology
Double-blind, cross-over, incomplete factorial study to assess the local anesthetic efficacy and safety of CTY-5339 Anesthetic Spray (CTY-5339A), Stage 2: Double-blind Active Comparator Phase
The purpose of this study is to see if one spray of CTY5339-A to the gums above the top front teeth produces longer numbness or better numbness than one spray of benzocaine alone.
Funding Source: Cetylite
Principal Investigator: Dr. Elliot Hersh, Professor
Department of Pathology
Bacteria and Lymphocyte Suppression in Periodontitis
The goal of the study is to determine the underlying mechanism by which a bacterial derived toxin, the cytolethal distending toxin (Cdt), acts to inhibit cell growth and induce cell death and thereby perturb host defenses. These studies will lead to a more detailed understanding of the toxin and provide: (1) important insight into the pathogenesis of disease caused by Cdt-producing bacteria and (2) a rationale on which therapeutic intervention may be developed to prevent or limit disease.
Funding Source: NIH
Principal Investigator: Dr. Bruce Shenker, Professor
Department of Periodontics
The role of NF-kB in Mesenchymal Stem Cells during Diabetic Wound Healing
This study will investigate how diabetes affects mesenchymal stem cells that are important for hard and soft tissue healing. It will test if diabetes activates an inflammatory protein, NF-kB, and mediates the negative effects in these stem cells. The studies may provide a novel therapeutic approach to target this protein to improve the function of the stem cells in the treatment of non-healing diabetic wounds.
Funding Source: NIH
Principal Investigator: Dr. Kang Ko, DScD candidate
Division of Community Oral Health
Expanding Pediatric Training in Predoctoral Dental Education
This project builds on existing efforts at Penn Dental Medicine to expand predoctoral education in both pediatric dentistry and community health to address persistent health disparities and difficulties in accessing oral health care in the medically underserved communities in West Philadelphia. The overall goal is to expand the knowledge, skills, and experiences of students in providing dental care with children birth to age 5.
Funding Source: Health Resources and Services Administration, NIH
Principal Investigator: Dr. Joan Gluch, Professor and Div. Chief
Penn Dental Journal,
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