CDE: [Dean’s Speaker Series] ft. Daniel Clark, DDS, MS, PhD

Mar, 2021
12:00 PM-01:00 PM

Virtually presented via Zoom Webinar

Time: 12:00-1:00 pm; This virtual lecture will begin promptly at 12:00 pm via Zoom Webinar.
Registration: FREE; Registration is still required.
Register here»
CE Credits: 1.0 lecture credits

An Osteoimmunological Approach to Inflamm-Aging: Implications for Periodontal Disease and Bone Regeneration

Course Description

This lecture will introduce the topic of inflamm-aging, which describes age-related changes to the inflammatory response and how such changes contribute to the increased prevalence of disease as we age. The speaker will be focus on how age-related changes to the inflammatory response contribute to complications in bone regeneration and to the pathogenesis of periodontal disease. Towards a mechanistic understanding, the speaker will discuss the role of the macrophage in regulating inflammation and how transcriptional and molecular changes that occur with age perturb macrophage function. Finally, the lecture will demonstrate the effect of targeting macrophages as a potential therapeutic for age-related pathologies.

Learning Objectives

The participants of this lecture will understand the role of macrophages in regulating inflammation and the pathological changes that occur with aging that contribute to periodontal disease or complications in bone regeneration. The participant will further appreciate the potential of immunomodulating therapies in the treatment of age-related pathologies.


Dr. Daniel Clark is an Associate Researcher at the University of California San Francisco School of Dentistry and a Diplomate of the American Board of Periodontology. Dr. Clark received his DDS from the University of Michigan School of Dentistry and completed his periodontology and PhD training at UCSF. Dr. Clark’s independent research program is interested in understanding the age-related changes that disrupt inflammatory regulation within bone. He focuses on the macrophage as a key regulator of inflammation and demonstrates how age-related changes perturb macrophage function during inflammatory propagation, resolution, and during regeneration. The work employs single-cell RNA sequencing to arrive at unbiased characterization of macrophage sub-populations that are temporally and spatially regulated during diverse phases of inflammation and regeneration within bone. Further, old and young mouse models of periodontal disease and bone regeneration are utilized to demonstrate the therapeutic potential of targeting macrophages to alleviate their pathological burden in old organisms.

Disclosure: Dr. Clark has no relevant financial relationships to disclose.

ADA Cerp

University of Pennsylvania School of Dental Medicine is an ADA CERP Recognized Provider. ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry.

University of Pennsylvania School of Dental Medicine designates this activity for 1.0 continuing education credits.