A number of student organizations and student chapters of professional organizations help to foster the social interaction and professional development of Penn Dental Medicine students. Following are the current active student groups compiled by the Penn Dental Medicine Executive Student Council:
| Academy of Osseointegration |
| American Academy of Developmental Medicine and Dentistry |
| American Association of Public Health Dentistry |
| American Student Dental Association |
| Art Club |
| Association for Dental Innovation and Advancement |
| Breaking Down Boundaries |
| Brown Sugar |
| Canadian Student Dental Association |
| Chinese Dental Association |
| Day of Service |
| Dental Innovators, Creators & Entrepreneurs |
| Ergo Club |
| Evolutionary Oral Medicine Club |
| Falun Dafa Club |
| First Generation Professionals |
| General Dentistry Society |
| Hispanic Student Dental Association |
| Implant Society |
| Indian Student Dental Association |
| Korean Student Dental Association |
| Meditation Club |
| Molar Yogis |
| Operation Smile |
| Ortho Society |
| Orthodontics Journal Club |
| PDM Aesthetics Society |
| PDM Student Business Organization |
| Penn Dental Christian Fellowship |
| Penn Dental Happiness Project |
| Penn Dental Jewelry Club |
| Penn Dental Medicine Outreach Program |
| Penn Dental Multidisciplinary Medicine Initiative |
| Penn Dental Pride Alliance |
| Penn Dental Sustainability Club |
| Penn Endodontic Society |
| Penn Military Dentistry Club |
| Penn Palate |
| Penn Pediatric Dental Society |
| Philadelphia Oral Cancer 5K/Walk |
| Philly Phaces at Penn Dental |
| Schoenleber Oral and Maxillofacial Surgery Society |
| Society of Oral Oncology |
| SoundBites |
| Student National Dental Association |
| Student Professionalism and Ethics Association (SPEA) |
| TMD Society |
| Vernon Brightman Research Society |