Edward T. Lally Memorial Lecture **CANCELLED**

Penn Dental Medicine
William W.M. Cheung Auditorium

*CANCELLED*

Please note the Edward T. Lally Memorial Lecture has been cancelled and will be rescheduled at a later date. Please contact the Office of Institutional Advancement with questions related to the event at alumni@dental.upenn.edu or 215-898-8951.

Time: 4:00pm-6:00pm
REGISTER NOW »
CE Credits: Coming Soon!

Lecture Description

In this Edward (Ned) T. Lally memorial lecture Dr. Peter Sebo will develop on the structure-function relationship, molecular mechanisms of action and role in bacterial pathogenesis of the broad family of so-called Repeat in ToXin (RTX) family leukotoxins that are secreted by the dedicated Type 1 secretion system by a variety of Gram-negative bacterial pathogens.

Dr. Sebo will summarize the contribution of Dr. Lally to the development of the entire research field. I will then follow by discussing the several families of RTX toxins, focusing on mechanisms of secretion, target cell receptor binding, membrane penetration, pore formation, enzyme delivery, cytotoxicity, signaling hijacking and use in vaccine development. I will document the various aspects of RTX leukotoxin action by using examples of our own results obtained with the adenylate cyclase toxin of the whooping cough agent Bordetella pertussis.

In memory of the passing of our Penn Dental Medicine colleague, Dr. Ned Lally, the Dr. Edward T. Lally fund was established to support the Edward T. Lally Memorial Lecture.

Dr. Lally was a proud University of Pennsylvania alumnus and was a part of the Penn Dental Medicine community for more than five decades. He played an integral role in advancing the excellence of our School, educating and mentoring generations of Penn Dental students and adding to our scholarly reputation.

Objective

• Understanding of key concepts of bacterial protein toxin action in hijacking of the immune defenses of the host

Speaker

Dr. Peter Sebo, PhD
Professor of Microbiology at the University of Chemistry and Technology in Prague
Head of Laboratory of Molecular Biology of Bacterial Pathogens at the Institute of Microbiology of the Czech Academy of Sciences in Prague, Czech Republic

Dr. Peter Sebo received his PhD in microbiology and molecular biology in Prague, Czechoslovakia and was a postdoc at the Institut Pasteur in Paris (1990-95) with Agnes Ullman. In 1995, he founded the Laboratory of Molecular Biology of Bacterial Pathogens at the Institute of Microbiology of the Czech Academy of Sciences (CAS) in Prague that he is heading till today.

From 2001-2005, Dr. Sebo held a Howard Hughes Medical Institute International Research Scholarship. Between 2008-2009, he founded and directed a new Institute of Biotechnology of the CAS in Prague and from 2006 to 2010 he conceived and led the project of a new biomedical research center of excellence, BIOCEV, jointly operated by the Czech Academy of Sciences and the Charles University in Prague. Dr. Sebo was elected to EMBO in 2013 and to the European Academy of Microbiology in 2016. Dr. Sebo also serves as professor of microbiology at the University of Chemistry and Technology in Prague.

The research of his team deals with molecular mechanisms of bacterial virulence and focuses mainly on the molecular and cellular mechanisms of Bordetella adenylate cyclase toxin action and its contribution to virulence of the whooping cough agent. Dr. Sebo is also involved in therapeutic and prophylactic vaccine work and published over 135 papers (H=37).

University of Pennsylvania School of Dental Medicine is an ADA CERP Recognized Provider. ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education. ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry.