Dr. Wolff has completed numerous international research and oral health assessment programs and has been a lifelong advocate and dental provider for individuals with physical, intellectual, and developmental disabilities of all ages. He has served as the principal or co-principal investigator on multiple benchtop and clinical research projects, investigating dental caries, novel remineralizing agents, dental erosion, periodontal disease, dental materials, and dentinal hypersensitivity. He has published over 100 scientific papers, text chapters, and edited multiple textbooks. Dr. Wolff lectures worldwide and is a frequent consultant to the industry. He has been the principal or co-principal investigator on nearly $9 million in industrial and National Institute of Health-funded research.