Dr. Yang’s research interests focus on exploring the mechanism of tooth and bone development, bone metabolism and mechanostransduction, as well as gene/stem cell therapy of bone diseases. Research in Dr. Yang’s lab has provided significant insights into the regulation of bone remodeling and bone resorption by the calcium oscillation, GPCR/G protein/RGS signaling pathways, primary cilia, IFT80 and IFT20 in regulation of bone cell behavior/bone and cartilage formation, which bridged the gap about the function and mechanism of RGS and ciliary IFT proteins in skeleton. Currently, the team is characterizing how RGS proteins regulates bone metabolism and aging skeleton. Additionally, studies are on the way to discover how ciliary IFT proteins and primary cilia affect tooth development, fracture healing and other bone related diseases. Those studies will lead to identification of novel regulatory cascades controlling fundamental bone developmental and remodeling processes and new insights in design of new therapeutic advances for bone and other diseases.