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The Center for Innovation & Precision Dentistry is bridging Penn Dental Medicine and Penn’s School of Engineering and Applied Sciences with cutting-edge research and training to accelerate the development of new solutions and devices to address unmet needs in oral health, while also recruiting and training the next generation of leaders in these fields.

Oral diseases affect 3.9 billion people worldwide, ranging from preventable tooth decay, to life threatening cancers. CIPD will contribute important knowledge about how to diagnose diseases earlier, and treat them more effectively. From developing new classes of personalized biomedical tools, to finding means to prevent certain diseases all together, the Center will foster innovation in dental medicine, engineering and the applied sciences.

Along with Penn Dental Medicine and Penn Engineering & Applied Sciences, the CIPD core partners include Penn Health Tech, Penn Center for Innovation, Institute for Biomedical Informatics, and the Center for Clinical & Translational Research.

Leadership/Executive Committee

Hyun (Michel) Koo, DDS, MS, PhD, Executive Director

Hyun (Michel) Koo, MS, PhD »
Department of Orthodontics, Division of Community Oral Health, Division of Pediatric Dentistry
Penn Dental Medicine

Dr. Koo’s research focuses on understanding the relationship between biofilms and oral infectious diseases and seeking novel therapeutic strategies to control pathogenic biofilms, including those associated with dental caries. He is searching for a compound therapy that can potentially disrupt the biofilm and cause S. mutans to be less potent in causing decay.

Kathleen Stebe, MSE, PhD, Director

Kathleen Stebe, MSE, PhD »
Goodwin Professor of Engineering and Applied Science
Penn Engineering

Dr. Stebe’s primary research interests are in non-equilibrium interfaces, with applications ranging from microfluidics to nanotechnology. One aspect of her research program focuses on interfaces between fluids and how surfactants can be used to influence interfacial flows. Other aspects address tailoring of solid-liquid interfaces with applications ranging from patterned electrodeposition to capillary-driven assembly and ordering of nanomaterials.

Henry Daniell, PhD, Co-Director

Henry Daniell, PhD »
Vice-Chair and W.D. Miller Professor
Department of Basic & Translational Sciences
Penn Dental Medicine

Dr. Daniell has developed a novel plant-based system that allows for the oral delivery of proteins and is effective in producing and delivering vaccines (for polio, tuberculosis, and malaria) and biopharmaceuticals the show promise for the treatment of Alzheimer’s, diabetes, pulmonary hypertension, hemophilia, muscular dystrophy, and retinopathy.

Anh Le, DDS, PhD, Co-Director

Anh Le, DDS, PhD »
Chair and Norman Vine Endowed Professor of Oral Rehabilitation
Department of Oral and Maxillofacial Surgery / Pharmacology
Penn Dental Medicine

Dr. Le’s research focuses on investigating mesenchymal stem cells from adult oral tissues. Together with collaborators, she isolated and characterized adult stem cells from gingival tissue—a discovery she patented while at USC.

Andrew Tsourkas, MS, Phd

Andrew Tsourkas, MS, PhD »
Professor, Department of Bioengineering
Co-Director, Center for Targeted Therapeutics & Translational Nanomedicine (CT3N)
Co-Director, Chemical and Nanoparticle Synthesis Core
Penn Engineering

The Tsourkas lab combines chemistry, nanotechnology, and protein engineering to create novel targeted imaging and therapeutic agents designed to improve the detection and treatment of cancer. Specific research interests include developing new nanoformulations that are capable of carrying extremely high payloads of drugs, sensitizing agents, and/or contrast agents; investigating new disease targeting strategies that maximize specificity and sensitivity; and developing new bioconjugation techniques that enable the highly efficient, site-specific labeling of targeting agents for imaging and therapeutic applications.

Jason Moore, PhD

Jason Moore, PhD »
Edward Rose Professor of Informatics & Director of the Penn Institute for Biomedical Informatics

Dr. Moore leads an active NIH-funded research program focused on the development of artificial intelligence and machine learning algorithms for the analysis of complex biomedical data with a focus on genetics and genomics. He is an elected fellow of the American Association for the Advancement of Science (AAAS), an elected fellow of the American College of Medical Informatics (ACMI), and was selected as a Kavli fellow of the National Academy of Sciences.

History of Innovation

Look back on the history of innovation at Penn Dental Medicine through some of the individuals who were leaders across the fields of dental medicine.


Center for Innovation & Precision Dentistry
Penn Dental Medicine
240 S. 40th Street
Philadelphia, PA 19104
215-898-8993 |