Coronavirus (COVID-19) Information and Resources

Information on the impact of coronavirus (COVID-19) on patient care and School/University operations. Plus, resources for the Penn Dental Medicine community and alumni.

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Ongoing Research Projects

Studies Open for Enrollment

The ARMOR Trial

The ARMOR Trial: Commensal Oral Microbiota as a Trigger of Oral Mucositis Severity
Principal Investigator(s): Patricia Corby, DDS, MS and Alexander Lin, MD
Study Status: Currently enrolling
This Study is Grant Funded by: National Institutes of Health — National Institute of Dental and Craniofacial Research

The ARMOR Trial is a randomized, controlled trial of a targeted oral care intervention in patients undergoing radiation or chemoradiation for head and neck cancer. The purpose of the study is to test whether this oral care procedure will delay the onset and reduce the severity, duration, and pain of oral mucositis, a debilitating side effect of radiation therapy. Eligible participants will be asked to attend one visit prior to beginning radiation therapy, weekly visits during radiation therapy, and one visit 3 months after completion of radiation therapy. In total, participants will attend approximately 11 visits over the course of approximately 5.5 months.

You may be eligible to participate if you are aged 18 years or older, are scheduled to undergo radiation or chemoradiation for head and neck cancer, have at least 6 natural teeth, and do not require antibiotic pre-medication prior to dental treatment.

If you are interested in learning more, please contact the study team at (917) 586-9089, PDM-ARMORTrial@dental.upenn.edu.

The OHART Study

The OHART Study: An observational study for patients living with HIV who have been on antiretroviral therapy for at least one year.
Principal Investigator: Temitope Omolehinwa, BDS, DScD
Study Status: Currently enrolling
This Study is Grant Funded by: National Institutes of Health — National Institute of Dental and Craniofacial Research

The OHART study is a collaborative effort between dental and medical experts, and is aimed towards improving outcomes for people living with HIV. This prospective study will identify oral-systemic non-AIDS-associated comorbid diseases (non-infectious diseases) in a large population of HIV individuals. The goal is to determine key oral health manifestations associated with development and severity of these diseases. A better understanding of the interplay between oral and systemic inflammation in people living with HIV can inform clinicians about novel preventive treatments aimed at reducing inflammation among people living with HIV.

For more information, and to see if you may be eligible, please contact the study team at (215)-908-5667, PDM-OHART@dental.upenn.edu

Pediatric Toothpaste Study

Pediatric Toothpaste Study: A Phase 2 randomized, double-blind, active-controlled multi-center clinical trial to assess the safety and the anti-caries efficacy of COL 101 (arginine) non-fluoride dentifrices with 1.5%, 4.0% and 8.0% arginine each in comparison with 0.24% sodium fluoride (1100 ppm F) dentifrice control in 10 to 14-year-old children.
Principal Investigator: David Hershkowitz, DDS, AAS
Study Status: Currently enrolling
This Study Sponsored by: Colgate-Palmolive

The purpose of this research study is to test how effective a new toothpaste is in reducing tooth cavities. This new toothpaste contains arginine, an essential amino acid that is naturally found in saliva and produced by the human body. In this study, we will compare regular fluoride toothpastes that you could buy in a store to this new toothpaste which contains arginine. 

Your child may be eligible for this study if they are aged 10-14 years, are in good general health, and have a history of dental cavities. Eligible participants will be asked to attend study visits once every 3 months for a year (5 visits in total) to have a dental exam and complete questionnaires. Participants will be given study toothpaste and a toothbrush to use throughout their participation in the study.

If you are interested in learning more, please contact the study team at PDMToothpasteStudy@dental.upenn.edu.

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